Tackling the opioid crisis in Alberta will require new approaches and an immediate response of the entire health system to change its trajectory. The engagement and response of primary care physicians, their teams and Primary Care Networks (PCNs) in Alberta will be essential in defining new primary health care approaches to address the crisis and the systemic issues that contribute to the crisis. The Alberta College of Family Physicians (ACFP), Alberta Medical Association (AMA) and Alberta Health Services (AHS), together with Alberta Health (AH) are aligned to lead this essential work to focus the primary care response.